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If you enjoy unique cocktail flavors or working with fresh herbs and spices you can make a lot of unique bitters such as coffee, celery and spice, key lime, or apple pie. You'll basically infuse raw ingredients into a liquid extract and then mix several singular extracts into liquid bitters blends.

Culinary weblog Adventures in Cooking recommends making a basic extraction by adding spices and herbs in a small mason jar with vodka. Depending on the spice, bark, or root it may take anywhere from 7-28 days for a full extraction.

Once you have your extractions set you'll just combine them using recipes or your own estimation. The source link below shares a dozen or so recipes, such as Bloody Mary bitters and the others mentioned above.

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DIY Bitters Pts I & II | Adventures in Cooking

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